Biomolecular Science - Silvana Andreescu
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Silvana Andreescu Assistant Professor Chemistry 206 Science Center Clarkson University PO Box 5810 Potsdam, NY 13699-5810 Phone: 315-268-2394 E-mail: eandrees@clarkson.edu |
Educational Background
Ph.D. University of Bucharest, Bucharest, Romania (Analytical Chemistry)
Ph.D. University of Perpignan, Perpignan, France (Agrochemistry)
Postdoctoral Fellowship, State University of New York at Binghamton
Research Interests
Our work lies in three main directions: microencapsulation techniques, bioremediation and biosensors. We are currently investigating the use of natural biopolymers in conjunction with nanoparticle based hybrid materials for the development of polymeric microcapsules with application in drug-delivery and bioremediation. We are focused on increasing the stability of the microcapsules and studying the time-released mechanism. We are also investigating the potential use of these systems for the encapsulation of biological material (cells and enzymes) for the construction of bioreactors. This will have application in catalytic processes in biotechnology and for the removal of organic pollutants from environmental matrices. In the field of biosensors, we are investigating new biomaterials for the purpose of increasing the selectivity and the stability of these devices.
Selected Publications
S. Andreescu, D.W. McGee, O.A. Sadik, Effect of Natural and Synthetic Estrogens on A549 Lung Cancer Cells: Correlation of Cytotoxic Effects to Chemical Structures, Chem. Res. Toxicol. 18, 2005, 446-474.
S. Andreescu, O.A. Sadik, D.W. McGee, S. Suye, Autonomous Multielectrode System for Monitoring the Interactions of Isoflavonoids with Lung Cancer Cells, Anal. Chem. 76, 2004, 2321-2330.
S. Andreescu, O.A. Sadik, The Correlation of Analyte Structures with Biosensor Responses using Structure-Activity Relationship: Detection of Phenolic Estrogens as Model, Anal. Chem. 76, 2004, 552-560.
S. Andreescu, O.A. Sadik, Trends & Challenges in Biochemical Sensors for Clinical and Environmental Monitoring, Pure Appl. Chem. 76(4), 2004, 861-878.
O.A. Sadik, A.K. Wanekaya, S. Andreescu, Advances in Analytical Technologies for Environmental Protection and Public Safety, J. Environ. Monit. (Critical review) 6, 2004, 413-522.
S. Andreescu, D. Andreescu, O.A. Sadik, A new electrocatalytic mechanism for the oxidation of phenols at platinum electrodes, Electrochem. Commun. 5(8), 2003, 681-688.
S. Andreescu, L. Barthelmebs, J.-L. Marty, Immobilisation of AChE on screen-printed electrodes; Comparative study between three immobilisation methods; Applications to the detection of organophosphorus insecticides, Anal. Chim. Acta 464, 2002, 171-180.
S. Andreescu, T. Noguer, V. Magearu, J.-L. Marty, Screen-printed electrode based on AChE for the detection of pesticides in presence of organic solvents, Talanta 57, 2002, 169-176.
S. Andreescu, A. Avramescu, C. Bala, V. Magearu, J.-L. Marty, Detection of organophosphorus insecticides with immobilized acetylcholinesterase: Comparative study between two enzyme sensors, Anal. Bioanal. Chem. 374, 2002, 39-45.
S. Andreescu, V. Magearu, A. Lougarre, D. Fournier, J.-L. Marty, Immobilization of enzymes on screen-printed sensors via an histidine tail. Application to the detection of pesticides using modified cholinesterase, Anal. Lett. 34(4), 2001, 429-540.
Recent Presentations
S. Andreescu, O.A. Sadik, Autonomous multielectrode system for monitoring cell growth and cytotoxicty of phenolic estrogens on lung cancer cells, Pittcon 2005, Orlando, Florida, February 27 – March 4, 2005.
J. Karasinski, S. Andreescu, O.A. Sadik, High-throughput oxygen sensor for monitoring bacterial pathogens, Pittcon 2005, Orlando, Florida, February 27 – March 4, 2005.
S. Andreescu, O.A. Sadik, D.W. McGee, S. Suye, Autonomous multielectrode system for monitoring cells growth and the interactions of isoflavonoids with lung cancer cells, Biosensors 2004, Granada, Spain, 23-27 May, 2004.
S. Andreescu, O.A. Sadik, The Correlation of Analyte Structures with Biosensor Responses using the Detection of Phenolic Estrogens as a Model Example, Pittcon 2004, Chicago, Illinois, March 7-12, 2004.
S. Andreescu, O.A. Sadik, How to prevent surface fouling during oxidation of phenolic compounds, 2003 EAS-Eastern Analytical Symposium, New Jersey, November 17-20, 2003.
O.A. Sadik, M. Breimer, A.K. Wanekaya, I. Kowino, S. Andreescu, C. Jacobs, Advances in environmental analytical technologies for homeland security, ASC National Meeting-Symposium Series, New York, September 7-11, 2003
Current Graduate Students
- John Njagi, Design and characterization of novel biocompatible materials for sensing and biosensing
- Cassandra Moulton, Microencapsulation of enzymes for clinical and environmental applications
Current Undergraduate Students
- John Warner, 2008, Chemistry & Biomolecular Science, (Bio)electrochemical methods for the removal of phenolic estrogens from wastewaters.