Biomolecular Science - Rajni Garg

Clarkson University » Department of Chemistry & Biomolecular Science » Faculty

Rajni Garg Research Associate Professor Chemistry 247 Science Center Clarkson University PO Box 5810 Potsdam, NY 13699-5810 Phone: 315-268-4421 E-mail: rgarg@clarkson.edu Web site

Education
Ph.D. 1996. Birla Institute of Technology and Science, Pilani, India - Chemistry
M.Phil. 1988. University of Delhi, Delhi, India - Chemistry
B.Ed. (Bachelor of Education) 1986. Meerut University, Meerut, India
M.Sc. 1984. Meerut University, Meerut, India - Organic Chemistry
B.Sc. 1982. Meerut University, Meerut, India - Chemistry

Research Interests
Structure-activity Relationships has been at the heart of chemistry ever since Mendeleyev began the construction of the periodic table. Hammett in 1935 showed how equations could be derived to describe and predict reaction mechanism of organic compounds in quantitative terms. Quantitative Structure-Activity Relationship (QSAR) is the science which relates chemical structure to biological activity quantitatively and gives important information about the mode of action of chemicals on biological systems - DNA, proteins, enzymes, cells and humans. This information can be used to optimize the synthesis of drugs, which results in considerable savings of time and money. QSAR is an important computer-aided drug design technique for understanding chemical-biological interactions. It correlates information on chemical structures to biological systems (Chem-bio Informatics). Data set mining through lateral validation of QSAR models allows us to develop a framework for making predictions.

Research in my lab is being pursued in the following three areas:

• Relational Drug Design
• Environmental Toxicity
• Chem-Bio Informatics and QSAR

Courses Taught
General Chemistry Laboratory(CM105): Fall 02
Biochemistry II (CM461/561, BY451): Spring 03
Medicinal Chemistry (CM444, CM544): Spring 04